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Perhaps she made a mistake in the lab, and a chemical burned her face or severely disfigured her, forcing her to wear this mask. Wonder Woman director Patty Jenkins described Dr. Poison as someone who has had all kinds of damage in her life in an interview with ScreenRant.
Wonder Woman: Doctor Poison's Toxic Legacy | DC. While Ares and Germany's real-life General Erich Ludendorff may serve as the two biggest adversaries in Wonder Woman, they're aided by the brilliant, deadly chemist named Isabel Maru, or as she's referred to by the British army—Doctor Poison.
This version is Dr. Isabel Maru, a chemist recruited by General Erich Ludendorff to create chemical weapons for the Imperial German Army during World War I. Additionally, she wears a ceramic mask over the left side of her face to cover a facial disfigurement.
Poison's work with poisonous gas and sponsored her research on behalf of the German military. Dr. Maru's severe facial scars came due to intentional exposure to one of her own gases. She covers them with special plates shaped and colored to imitate human flesh, as was actually done during the time.
Elena Anaya. Film. An original incarnation of Doctor Poison appears in Wonder Woman, portrayed by Elena Anaya. This version is Dr. Isabel Maru, a chemist recruited by General Erich Ludendorff to create chemical weapons for the Imperial German Army during World War I.